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Examples
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Burkitt's is a disease we like to treat because they do really well, they feel better so quickly, LaCasce said.
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Burkitt's is a disease we like to treat because they do really well, they feel better so quickly, LaCasce said.
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The intention was to prove that EBV DNA persists in every tumour cell of Burkitt's lymphoma and does not establish a persistent infection there, as assumed at that time by a number of my former colleagues.
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LaCasce, who said she treats four to five cases of Burkitt's a year, said the prognosis for the rare subtype of non-Hodgkin lymphoma is usually very good, particularly for children and young adults who can tolerate the high toxicity that the aggressive chemo entails.
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By the end of 1969 I had the first data available that the non-EBVproducing Burkitt's lymphoma cell line Raji contained multiple copies per cell of EBV DNA.
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Shortly thereafter it was also possible to demonstrate EBV DNA in Burkitt's lymphoma and nasopharyngeal cancer biopsies.
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I started to work eagerly on the induction of specific chromosomal aberrations in adenovirus type 12-infected human cells, simultaneously studying a DNA-replication disturbance of individual chromosomes in human lymphoblastoid and lymphoma cell lines, and, to please my mentor, I demonstrated electron microscopically the presence of EBV particles directly in individual serologically antigen-positive Burkitt's lymphoma cells.
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With the aid of Werner Henle in Philadelphia and George Klein in Stockholm I received a large number of Burkitt's lymphoma cell lines and tumour biopsies.
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They had noted early that Burkitt's lymphoma patients developed high antibody titres against viral antigens.
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Burkitt's is a disease we like to treat because they do really well, they feel better so quickly, LaCasce said.
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