from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A glycoprotein predominantly found on the surface of helper T cells. In humans, it is a receptor for HIV, enabling the virus to gain entry into its host.
- n. A cell bearing the CD4 surface receptor.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- abbr. A glycoprotein found on the surface of helper T cells; in humans, it enables the HIV virus to enter a cell
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a glycoprotein that is found primarily on the surface of helper T cells
In order to define the target antigens and the relative immunodominance of the overall HIV-1-specific CD4 T cell response in clade C virus infection, we used an IFN-γ Elispot assay to screen for HIV-1-specific CD4+ responses using an overlapping peptide set spanning the entire HIV-1 clade C proteome in 32 randomly selected subjects.
(B-D) Foxp3 expression in splenic CD4+ T cells 8 (B) or 14 (C) d after infection, and in sub-mandibular lymph node CD4
An international team has developed the prototype CD4 rapid test, similar in design to a home pregnancy test, which works with a finger-prick blood sample to measure the numbers of CD4+ T-cells in a person's blood.
Dot plots - top: gated on CD3+B220 − cells: CD4 versus CD8, middle: gated on SP CD4+ T cells showing the Vβ8. 2+ tumor cell population and an irrelevant Vβ-chain (Vβ6); bottom: gated on DP CD4/Vβ8. 2 as shown in histogram all other Vβ-families were negative.
More specifically, researchers observed rapid and sustained immunological reconstitution in terms of CD4 and CD8 lymphocyte counts and high frequencies of specific CD4+ and CD8+ cells against microbial agents together with a significant reduction in post-transplant cytomegalovirus reactivation.
+CD8 − lymphocytes, which are further referred to as CD4
HIV infects immune cells called CD4 T-cells (also called helper T cells) and slowly begins to decrease their numbers.
The severity of HIV infection is measured by a count of white blood cells expressing a protein called CD4 for cluster of differentiation 4.
Every T4 cell has appendages called CD4 receptors, through which it exchanges information with other immune cells.
Yet, like an AIDS patient, she has virtually lost a vital class of immune cells known as CD4 lymphocytes.