Dkk

Staining with the cTEC specific DEC205 antibody revealed a severely hypoplastic cortex in Dox-treated TetO-Dkk1 mice.

PLoS ONE Alerts: New Articles Masako Osada et al. 2010

The decline in T cell number in TetO-Dkk1 mice appears to be the result of the loss in epithelial niches required to support thymocyte development, rather than a direct effect of DKK1 on the thymocytes themselves.

PLoS ONE Alerts: New Articles Masako Osada et al. 2010

Representative scans shown for cortical areas in figure 1C (red arrow represents scan), together with the histograms showing the reduced Foxn1 staining intensity in the Dox treated TetO-Dkk1 thymus.

PLoS ONE Alerts: New Articles Masako Osada et al. 2010

The mean Foxn1 fluorescence intensity was calculated from both cTECs and mTECs derived from 4-week Dox treated ST or TetO-Dkk1 mice (based on their location within DEC205+ and K14+ regions of the thymus).

PLoS ONE Alerts: New Articles Masako Osada et al. 2010

When male TetO-Dkk1 mice were surgically castrated prior to initiating Dox feeding, more modest reductions in thymic size comparable to TetO-Dkk1 females were observed (data not shown), supporting a synergy between androgen driven thymic involution and the degeneration induced by DKK1 expression in TECs.

PLoS ONE Alerts: New Articles Masako Osada et al. 2010

DKK1 mutations on bone mass in humans, there is hallmark evidence for an over-production of DKK1 in human cancer cells being responsible for the development of osteolytic lesions associated with metastatic bone disease Albeit Dkk1 can inhibit Wnt signalling through a direct interaction with Lrp5 or Lrp6, its antagonistic function is significantly enhanced by members of the Kremen (Krm) family, which serve as high affinity receptors for Dkk proteins

PLoS ONE Alerts: New Articles Jochen Schulze et al. 2010

(A) RT-PCR expression analysis of Dkk, Krm and Rspo genes in primary osteoblasts (Obl. d5, non-mineralized, Obl. d25, mineralized) and various tissues of 6 weeks old mice.

PLoS ONE Alerts: New Articles Jochen Schulze et al. 2010

Krm genes and their potential ligands of the Dkk and Rspo family by RT-PCR using cDNA from tissues of 6 weeks old mice.

PLoS ONE Alerts: New Articles Jochen Schulze et al. 2010

Here we show, that the transmembrane protein Krm2, which serves as a receptor for Wnt antagonists of the Dkk family

PLoS ONE Alerts: New Articles Jochen Schulze et al. 2010

Low magnification images derived from Dox-treated TetO-Dkk1 mice revealed loss of ΔNp63

PLoS ONE Alerts: New Articles Masako Osada et al. 2010