from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A congenital disorder caused by the presence of an extra 21st chromosome and marked usually by moderate to severe mental retardation, short stature, and a flattened facial profile.
from the GNU version of the Collaborative International Dictionary of English.
- noun (Med.) A congenital disorder caused by an extra chromosome 21 in some or all cells. It causes a variable number and degree of abnormalities, including retarded growth, mental retardation, a short nose, prominent epicanthic folds on the eyelids, a protruding lower lip, and other physical features having varying degrees of deviation from the normal. Called also
mongolism, trisomy-21and trisomy 21 syndrome.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Condition caused by a
chromosomal excess, whereby the patients bear a certain resemblanceto the Mongoloidrace, such as a small head and tiltedeyelids, and typically have a delay in cognitive ability and physical growth.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation
from The American Heritage® Dictionary of the English Language, 4th Edition
[After John Langdon Haydon Down, (1828–1896), British physician.]
from Wiktionary, Creative Commons Attribution/Share-Alike License
Named after John L.H. Langdon-Down (1828-1896), an English physician who described it in the late 1800s. The term was first used in 1961.
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