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Examples
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Blaschuk, OW, et al. E-cadherin, estrogens and cancer: is there a connection?
T.S. Wiley: Estrogen Dilemma: There Is No Dilemma When You Know the Details T.S. Wiley 2010
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E-cadherin is probably the best understood cadherin.
Cadherins, Part 1 2007
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The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and therefore to E-cadherin function.
Cadherins, Part 1 2007
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The group discovered that by activating C-Met, Internalin B hastens the uptake of cell-surface molecules, including E-cadherin, at villus tips where cells have been shed.
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Oddly, though, both E-cadherin and C-Met are typically located along the normally inaccessible sides of villus cells.
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The new study throws light on the subtle role played by Internalin B once Internalin A locks onto E-cadherin.
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Internalin B can accelerate the uptake of E-cadherin, along with the bug that's clinging to this molecule.
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Below, confocal images of E-cadherin immunostaining of HRasG12V-transformed MDCK-F3 cells show restoration of E-cadherin expression at the cell-cell interfaces after treatment with 50 μM palmostatin B.
Naturejobs - All Jobs Frank J Dekker 2010
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Amieva's group had also previously shown that Internalin A is able to find E-cadherin only at the special remodeling junctions that occur as cells are being shed from the epithelial lining.
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Internalin A's targeted molecule, E-cadherin, is a key player in forging the junctions between adjacent cells of the gut epithelium.
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