from Wiktionary, Creative Commons Attribution/Share-Alike License

  • abbr. avian erythroblastosis oncogene B 2.
  • n. Alternative spelling of HER-2.


from Wiktionary, Creative Commons Attribution/Share-Alike License

ErbB2 was named for its similarity to ErbB (avian erythroblastosis oncogene B).


  • The formal name is “human epidermal growth factor receptor,” and it is also known as HER-2, c-erbB-2, ErbB-2, and ERBB2.

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  • Multiple membrane-bound receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR) and ErbB-2, have been reported to be localized in the nucleus, where emerging evidence suggests that they are involved in transcriptional regulation, cell proliferation, DNA repair and chemo - and radio-resistance.

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  • Kochupurakkal BS, Yarden Y (2004) The Achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

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  • In vivo activity of ARRY-380: A potent, small molecule inhibitor of ErbB-2 in combination with trastuzumab or docetaxel in a BT-474 human breast carcinoma xenograft model


  • Array-380 our ErbB-2 program for breast cancer, we planned on by the fourth quarter, we haven't hit it yet, completing the Phase 1 escalating dose trial and we will report on those results at the San Antonio Breast Cancer Meeting in December.

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