from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The name of a structural motif, and associated protein, first identified in cyclin-F


Sorry, no etymologies found.


  • Lecker SH, Jagoe RT, Navon A, Goldberg AL (2001) Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.

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  • "This methodology is widely applicable," says Kishi, "and in collaboration with other groups, we have succeeded in identifying targets of other F-box proteins."


  • "Although the identification of substrates is essential for our understanding of cellular regulatory mechanisms involving ubiquitination, identifying them is quite difficult," explains Tsutomu Kishi of the Advanced Science Institute in Wako, whose work on ubiquitin ligase target recognition via subunits known as 'F-box proteins' has been impeded by the limitations of existing tools for protein-protein interaction analysis.


  • As RPM-1 forms an E3 ubiquitin ligase complex with the F-box protein FSN-1 and the Cullin CUL-1

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  • First, RPM-1 forms an SCF-like complex with the F-box protein FSN-1, the SKP1 ortholog SKR-1, and the Cullin CUL-1; the resulting ubiquitin ligase ubiquitinates DLK-1, an upstream component of a

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  • Among these genes is cdc34, the ubiquitin-conjugating enzyme of the Skp1 / cullin / F-box

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  • Clayton CE (2007) The F-box protein CFB2 is required for cytokinesis of bloodstream-form Trypanosoma brucei.

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  • Dia2 is an F-box protein, which is involved in the regulation of DNA replication in the budding yeast

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  • The F-box domain is shown in blue, and five alleles of an are indicated with their DNA sequence changes shown below the blue bar.

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  • Zhang S, Sandal N, Polowick PL, Stiller J, Stougaard J, et al. (2003) Proliferating Floral Organs (Pfo), a Lotus japonicus gene required for specifying floral meristem determinacy and organ identity, encodes an F-box protein.

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