Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A retrovirus associated with certain leukemias and lymphomas and with demyelinating diseases such as multiple sclerosis

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

h(uman) T(-cell) l(ymphotropic) v(irus) I.

Examples

  • This study builds on earlier work by Lairmore and his colleagues showing that HTLV-I produces proteins that activate infected immune cells and causes them to divide, thereby increasing the number of infected cells in the body.

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  • Lairmore and his colleagues examined HTLV-I infection in rabbits that were treated with the drug cyclosporin A, which is commonly used to suppress the immune system in people following organ transplantation.

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  • Gilmartin GM, Hanly SM, Nevins JR, Greene WC (1991) The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation.

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  • Cavanagh MH, Landry S, Audet B, Arpin-Andre C, Hivin P, et al. (2006) HTLV-I antisense transcripts initiating in the 3′LTR are alternatively spliced and polyadenylated.

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  • Earlier we showed that IKKγΔ is a dominant negative inhibitor of HLTV-I Tax induced NF-κB activation, despite the ability of both isoforms to bind HTLV-I Tax protein

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  • * Human T-cell leukemia virus-I (HTLV-I) - This virus causes a rare type of chronic lymphocytic leukemia known as human T-cell leukemia.

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  • Samuel KP, Kan NC, Ascione R, Wong-Staal F, et al. (1985) Production of oncogene-specific proteins and human T-cell leukemia (lymphotropic) retrovirus (HTLV-I) envelope protein in bacteria and its potential for use in human cancers and seroepidemiological surveys.

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  • (IKK) - γ, IKKγ − Δ, Differentially Mediates Cytokine And HTLV-I Tax Induced NF-κB Activation.

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