Humulin

The biggest drugs knocked off the list, with combined U.S. sales of about $1.7 billion, are Eli Lilly & Co . insulin products called Humulin and Humalog.

CVS Disfavors Some Drugs Jon Kamp 2011

Lilly sees continued sales growth for Cymbalta, erectile-dysfunction drug Cialis, and diabetes drugs Humalog and Humulin.

For Lilly, Rocky Year Ahead Peter Loftus 2012

One type, Humulin, was the first biologic marketed, in 1982.

John Horton: Biologics: Are Unsafe Drugs an 'Acceptable Risk?' FDA Should Say 'No!' John Horton 2010

"Our primary issue remains performance of key brands including declining U.S. volume trends for Zyprexa, Strattera, Evista, and Humulin/Humalog," he said.

Eli Lilly's Earnings Growth Seen Outpacing Peers 2006

It is this chemically engineered molecule that is sold under the name of Humulin.

'Genes in the Food': An Exchange Fuller, Colleen 2001

In 1995, Humulin insulin, manufactured by Eli Lilly, was the eighth-most-reported drug for adverse effects in the United States.

'Genes in the Food': An Exchange Fuller, Colleen 2001

In the case of Humulin, the clinical trial history leaves a lot to be desired.

'Genes in the Food': An Exchange Fuller, Colleen 2001

A few weeks after approval was granted, Dr. Solomen Sobell of the FDA reported that in clinical testing of the synthetic insulin, human antibodies formed despite expectations that Humulin would not cause an immune response.

'Genes in the Food': An Exchange Fuller, Colleen 2001

Suppose that Humulin is, in fact, just as active, or, worse still, more active than the insulin produced normally in our bodies.

'Genes in the Food': An Exchange Fuller, Colleen 2001

The first molecule was cloned in 1979 by Genentech, clinical trials began in 1981, and the product, Humulin, was on the market in early 1983.

'Genes in the Food': An Exchange Fuller, Colleen 2001