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Examples
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The structure also controls the binding of ATP competitive compounds, such as Imatinib (Gleevec®), the chronic myeloid leukemia (CML) treatment that is the first approved drug targeting another kinase, Abl, in rapidly dividing cancer cells.
Emaxhealth 2009
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Imatinib marketed as Gleevec, the first therapy that targets a specific enzyme expressed by cancer cells—rather than just kill cells that are dividing, like most chemotherapy—has now been saving lives for 10 years and is approved for 10 kinds of cancer.
The Latest Weapon Against Cancer: Evolution Matt Ridley 2011
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He highlights the drug Imatinib, marketed by Novartis as Gleevec in the United States, which is approved to treat a certain type of chronic myeloid leukemia and another type of cancer called gastrointestinal stromal tumor.
Genetic research venture in Fairfax County loses funding and falls apart 2010
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Shah et al., “Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor,” Science 305, no.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Shah et al., “Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor,” Science 305, no.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Shah et al., “Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor,” Science 305, no.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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He highlights the drug Imatinib, marketed by Novartis as Gleevec in the United States, which is approved to treat a certain type of chronic myeloid leukemia and another type of cancer called gastrointestinal stromal tumor.
Genetic research venture in Fairfax County loses funding and falls apart 2010
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I ran into a patient at a farmers market with his girlfriend and got introduced .... then he told me he wasn't taking a medicine that he had been prescribed (Gleevec/Imatinib .... horrendously expensive anti cancer drug).
Close Encounters aka TBTAM 2008
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Vogelstein pointed to Gleevec, a leukemia drug known generically as Imatinib, as an exception that proves the rule: It targets tyrosine genes, and is one of the few modern cancer drug success stories.
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Vogelstein pointed to Gleevec, a leukemia drug known generically as Imatinib, as an exception that proves the rule: It targets tyrosine genes, and is one of the few modern cancer drug success stories.
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