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The first major transformation was the progressive, but never complete, displacement, from about 1890 onwards, of hand-setting by the introduction of Linotype, Monotype and other hot-metal machines, notably Intertype and Ludlow.
The books we’ve done in the print shop have been my favorite projects (who gets to make a book with their own hands from liquid metal to bound pages anymore? not so many of us) and I loved the irony of setting a story about a Linotype on a Linotype (well, an Intertype; an improvement).