from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. See mountain goat.


Sorry, no etymologies found.


  • A key role for the Wnt signaling cascade in controlling thymocyte cellularity and differentiation is apparent from studies using Tcf-1/LEF-1 knockout mice, as well as a number of complementary gain-of-function and loss-of-function studies

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  • Amsterdam A, Grosschedl R (1991) DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1.

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  • Behrens J. von Kries J. P, Kühl M, Bruhn L, Wedlich D, et al. (1996) Functional interaction of beta catenin with the transcription factor LEF-1.

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  • Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, et al. (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

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  • Amsterdam A, Belanger C, Grosschedl R (1991) LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].

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  • Okamura RM, Sigvardsson M, Galceran J, Verbeek S, Clevers H, et al. (1998) Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.

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  • This newly characterized interaction involves three signaling components known to correlate with invasive cancer - activation of EGFR, elevated protein kinase CK2 activity, and increased beta-catenin - T-cell factor/lymphoid enhancer factor (TCF/LEF-1) transcriptional activity.

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  • Hay ED, Goodenough DA (2006) Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition.

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