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Examples
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The surge that worries Mayeux is Alzheimer's disease: In 2050, 13.5 million Americans may have it, at an annual health-care cost of more than $1 trillion, according to the Alzheimer's Association.
Researchers hope to quell a surge of Alzheimer's cases with new diagnostic tools 2010
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Mayeux, the Alzheimer's conference leader, agreed.
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The results, if verified by others, could lead to a better understanding of how this disease destroys the brain and causes symptoms such as memory loss, Mayeux says.
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People who inherit certain variations in the gene, called SORL1, appear to have an increased risk of getting Alzheimer's after age 60, says researcher Richard Mayeux at the Columbia University Medical Center.
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"Our study says that changes in the SORL1 gene might be a cause of the disease," Mayeux says.
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Mayeux, along with Lindsay Farrer, chief of the genetics program at Boston University School of Medicine and others, published the finding Sunday in the online edition of Nature Genetics.
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"As a pot-smoking, indignant 17-year-old he's credible, but [Kal] Penn made his name with the stoner hit Harold and Kumar Go to White Castle," writes Sara Mayeux.
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In a 1996 survey of 1,300 elderly women, Mayeux found that those who'd taken the hormone after menopause reduced their Alzheimer's risk by half -- regardless of family history.
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But because head trauma is so rare, Mayeux doubts it accounts for more than 1 percent of cases.
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Paris has an AEsop – Mayeux, and a Canidia, Mademoiselle Lenormand.
Les Miserables 2008
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