from The American Heritage® Dictionary of the English Language, 5th Edition.

  • An ancient region of southwest Asia between the Tigris and Euphrates Rivers in modern-day Iraq. Probably settled before 5000 BC, the area was the home of numerous early civilizations, including Sumer, Akkad, Babylonia, and Assyria. It declined in importance after Mongol invaders destroyed its extensive irrigation system in AD 1258.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • proper noun A region in Southwest Asia spanning from the rivers Euphrates and Tigris that is the site of one of the most ancient civilizations in the history of man.
  • proper noun The British Mandate of Mesopotamia, a League of Nations mandate from 1920 to 1932 that was the precursor to the independent state of Iraq.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun the land between the Tigris and Euphrates; site of several ancient civilizations; part of what is now known as Iraq


from Wiktionary, Creative Commons Attribution/Share-Alike License

From Ancient Greek Μεσοποταμία (Mesopotamía), from μέσος (mésos, "between") + ποταμός (potamós, "river"), because Mesopotamia is located between rivers Euphrates and Tigris.



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