N-cadherin

(DOR) promotes the processing of Aβ precursor protein (APP) by BACE1 and γ-secretase, but not that of Notch, N-cadherin or APLP.

Naturejobs - All Jobs 2010

(DOR) promotes the processing of Aβ precursor protein (APP) by BACE1 and γ-secretase, but not that of Notch, N-cadherin or APLP.

Naturejobs - All Jobs Lin Teng 2010

Scientists blocked surface molecules, proteins called N-cadherin, on the neural crest cells that are involved in forming contacts between cells.

PhysOrg.com - latest science and technology news stories 2010

It is expected that inhibition of N-cadherin would have the same the effect in cancer cells, which also move in groups during metastasis.

PhysOrg.com - latest science and technology news stories 2010

Green, mCD8-GFP, labeling LN processes; red, synaptotagmin-HA, a marker for presynaptic terminals; blue, nc82 or N-cadherin staining, highlighting glomerular structures.

Naturejobs - All Jobs Ya-Hui Chou 2010

To determine the functional relevance of these findings, we tested the effects of ERK and PI3K inhibitors on cell proliferation induced by Wnt. As shown in N-cadherin overexpression negatively regulates ERK and PI3K signalling.

PLoS ONE Alerts: New Articles Eric Haÿ et al. 2009

Finally, we found that the decreased cell survival induced by N-cadherin overexpression was reversed by Wnt and antagonized by PI3K inhibition.

PLoS ONE Alerts: New Articles Eric Haÿ et al. 2009

Mechanisms by which N-cadherin decreases cell survival.

PLoS ONE Alerts: New Articles Eric Haÿ et al. 2009

The altered cell survival induced by N-cadherin overexpression is Wnt - and PI3K/Akt-dependent.

PLoS ONE Alerts: New Articles Eric Haÿ et al. 2009

Tibias from 1.5 month old female N-cadherin transgenic and wild type mice and primary osteoblasts isolated from calvarias by sequential collagenase digestion were obtained as described

PLoS ONE Alerts: New Articles Eric Haÿ et al. 2009