Definitions
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Examples
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Namely, the massaged samples had less of a protein called NF-kB, which plays a role in creating an inflammatory response to exercise.
The Full Feed from HuffingtonPost.com Meredith Melnick 2012
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Hyperoxia-induced NF-kB activation occurs via a maturationally sensitive atypical pathway.
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Raw264. 7 cell lines constitutively expressing a dominant negative Irf3 (IRF3DN) or a general inhibitor of NF-kB (IkBα super-repressor, IkBαDN) were stimulated with LPS as indicated and Ccl5 mRNA or upstream extragenic transcripts were measured by RT Q-PCR.
PLoS Biology: New Articles Francesca De Santa et al. 2010
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Moreover, the NF-kB subunit p65/RelA was recruited to the Ccl5 upstream region (Figure 7C), thus further supporting the functionality of the identified sites.
PLoS Biology: New Articles Francesca De Santa et al. 2010
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Selected enriched PWMs for inflammatory TFs (IRFs, STAT1, NF-kB) are shown on the right.
PLoS Biology: New Articles Francesca De Santa et al. 2010
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NF-kB and the IRFs, (3) the functionality of some tested regions in heterologous reporter assays, and most importantly, (4) the very extensive overlap between sites of extragenic transcription and binding sites for the TF PU. 1, which is required for macrophage differentiation
PLoS Biology: New Articles Francesca De Santa et al. 2010
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TFs activated by stimulation with LPS+IFNγ include NF-kB/Rel family members
PLoS Biology: New Articles Francesca De Santa et al. 2010
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(C) Binding of NF-kB to the Ccl5 promoter and to a region corresponding to the
PLoS Biology: New Articles Francesca De Santa et al. 2010
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Some of the inducible Pol_II peaks in the region upstream of Ccl5 scored positively for IRF3 (as well as other IRFs) and NF-kB, which are known to coregulate Ccl5 expression
PLoS Biology: New Articles Francesca De Santa et al. 2010
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Interestingly, maximal p65 recruitment to this region preceded recruitment to the NF-kB binding sites contained in the
PLoS Biology: New Articles Francesca De Santa et al. 2010
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