from The American Heritage® Dictionary of the English Language, 4th Edition
- abbr. nerve growth factor
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. National Golf Foundation.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a protein that is involved in the growth of peripheral nerve cells
Sorry, no etymologies found.
NGF is found in mammals, birds, reptiles, amphibians and fishes.
The chemical structure of NGF is now known to consist of 118 amino acids.
Stanley Cohen, who purified NGF, is also the discoverer of epidermal growth factor or EGF.
Rita Levi-Montalcini showed, in a series of brilliantly performed studies, that NGF is not only necessary for the survival of certain nerves but also regulates the directional growth of the nerve fibres.
The nerve cells die when NGF is blocked by antibodies.
NGF is produced by the target cells which lure the nerve fibres to grow in the direction.
These strategies also allowed a prolonged delivery of NGF, but the safety of the method and the long-term NGF expression by transgene still need to be determined.
The subsequent demonstration that labelled NGF is taken up by the nerve endings of sympathetic  or sensory fibers  and is retrogradely transported to the cell perikarya, lent strong support to the concept of NGF as a strophic messenger, conveyed through nerve fibers from peripheral cells to the innervating neurons.
Nerve fibres grow towards the source of NGF which is taken up in the fibre ends and transported back to the nerve cell body.
Alternatively, in these cases NGF may subserve other functions which may somehow be linked with the poisonous action of snake venom, one can envisage the possibility that a highly specific neurotropic molecule such as NGF is utilized by reptiles as a carrier of other neurotoxins devoid of specific receptors in the central and peripheral nervous systems.