Definitions

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  • noun Plural form of NMJ.

Etymologies

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Examples

  • Whereas rpm-1 mutants have disorganized presynaptic terminals at motorneuron NMJs, we find that presynaptic terminals at interneuron central synapses of rpm-1 mutants are normal at a gross level.

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  • Numerous regulators of presynaptic terminals at neuromuscular junctions (NMJs) have been identified.

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  • Little is known about the function of PHR proteins like RPM-1 outside of the presynaptic terminal of NMJs, although they are abundantly expressed in the CNS.

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  • Interestingly, p38 MAPK signaling is the target of RPM-1 regulation at both central synapses and NMJs, suggesting that these genes function as a signaling cassette.

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  • (I) The number of fluorescent structures (puncta) is plotted for motorneuron NMJs.

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  • PHR proteins have both E3 ubiquitin ligase activity and guanine nucleotide exchange factor (GEF) activity, and can bind to Myc, adenylate cyclase, tuberin, the co-SMAD Medea, and dual leucine zipper kinases (DLKs) known to regulate the p38 MAP Kinase (MAPK) pathway A particularly well-studied PHR protein is RPM-1, which regulates the formation of NMJs by two parallel mechanisms.

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  • We quantified the total number of the dorsal cord SNB-1:: GFP boutons in rpm-1 (od14) mutants, and found it to be similar to that observed in known alleles of Differential requirements for RPM-1 at NMJs versus central synapses.

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  • Third, while mutations in rpm-1 result in defective presynaptic boutons at motorneuron NMJs, these same mutations do not appear to alter presynaptic boutons at interneuron central synapses.

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  • RPM-1 is required for proper presynaptic bouton formation at motorneuron NMJs

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  • SNB-1:: GFP fluorescence was observed along the ventral cord of animals either (A, C, E, G) expressing the reporter at motorneuron NMJs via the unc-25 promoter, or (B, D, F, H) expressing the reporter at interneuron central synapses via the glr-1 promoter.

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