Definitions
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- noun Plural form of
NMJ .
Etymologies
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Examples
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Whereas rpm-1 mutants have disorganized presynaptic terminals at motorneuron NMJs, we find that presynaptic terminals at interneuron central synapses of rpm-1 mutants are normal at a gross level.
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Numerous regulators of presynaptic terminals at neuromuscular junctions (NMJs) have been identified.
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Little is known about the function of PHR proteins like RPM-1 outside of the presynaptic terminal of NMJs, although they are abundantly expressed in the CNS.
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Interestingly, p38 MAPK signaling is the target of RPM-1 regulation at both central synapses and NMJs, suggesting that these genes function as a signaling cassette.
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(I) The number of fluorescent structures (puncta) is plotted for motorneuron NMJs.
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PHR proteins have both E3 ubiquitin ligase activity and guanine nucleotide exchange factor (GEF) activity, and can bind to Myc, adenylate cyclase, tuberin, the co-SMAD Medea, and dual leucine zipper kinases (DLKs) known to regulate the p38 MAP Kinase (MAPK) pathway A particularly well-studied PHR protein is RPM-1, which regulates the formation of NMJs by two parallel mechanisms.
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We quantified the total number of the dorsal cord SNB-1:: GFP boutons in rpm-1 (od14) mutants, and found it to be similar to that observed in known alleles of Differential requirements for RPM-1 at NMJs versus central synapses.
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Third, while mutations in rpm-1 result in defective presynaptic boutons at motorneuron NMJs, these same mutations do not appear to alter presynaptic boutons at interneuron central synapses.
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RPM-1 is required for proper presynaptic bouton formation at motorneuron NMJs
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SNB-1:: GFP fluorescence was observed along the ventral cord of animals either (A, C, E, G) expressing the reporter at motorneuron NMJs via the unc-25 promoter, or (B, D, F, H) expressing the reporter at interneuron central synapses via the glr-1 promoter.
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