Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. The Christian church characterized by an episcopal hierarchy with the pope as its head and belief in seven sacraments and the authority of tradition.

Etymologies

Sorry, no etymologies found.

Examples

  • Previous research had strongly implicated a well-known oncogene, or cancer-causing gene, called Notch1 in the initiation and progression of T-ALL in patients.

    PhysOrg.com - latest science and technology news stories

  • These SCL-LMO-primed cells then acquire mutations in a third gene, Notch1, which is known to play a role in the majority of T-ALL patients, "explains Trang Hoang.

    PhysOrg.com - latest science and technology news stories

  • Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1.

    Alagille Syndrome Related Reading

  • Loss of both Notch1 and Notch2, or RBP-J, but not Notch1 or Notch2 alone, leads to the development of a severe skin phenotype.

    PLoS ONE Alerts: New Articles

  • Mammucari C, Millar SE, Brisken C, Dotto GP (2005) p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.

    PLoS ONE Alerts: New Articles

  • Mice lacking Notch2 in the epidermis are indistinguishable from controls, whereas Notch1 deficient mice show K14 expression throughout the epidermis (whereas it is confined to the basal layer in controls), have a hyperproliferative epidermis and a mild increase in toluidine blue positive mast cells.

    PLoS ONE Alerts: New Articles

  • Mandinova A, Ostano P, Kolev V, Calpini V, et al. (2007) Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.

    PLoS ONE Alerts: New Articles

  • A long-term consequence of Notch1 deficiency in adult skin is the development of skin tumors, suggesting that in addition to regulating differentiation processes in the skin, Notch signaling is also associated with tumor suppressive functions Here, we show that simultaneous ablation of Notch1 and Notch2 signaling in the adult skin results in a severe form of atopic dermatitis-like disease as a result of highly elevated levels of TSLP.

    PLoS ONE Alerts: New Articles

  • Postnatal K5-Cre ERT mediated inactivation of Notch1 in the skin results in hyperproliferation with expansion of the proliferative basal cell layer, hair loss and epidermal cyst formation within less then one month

    PLoS ONE Alerts: New Articles

  • In postnatal skin, Notch signaling is predominantly mediated through the Notch1 and Notch2 receptors

    PLoS ONE Alerts: New Articles

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.