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Examples
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Omacetaxine mepesuccinate is administered subcutaneously and acts differently from TKIs.
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Omacetaxine has completed two phase 2/3 clinical trials for subsequent indications within CML and has been granted Orphan Drug designations by the U.S.
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Omacetaxine is a first-in-class cetaxine with demonstrated clinical activity as a single agent in a range of hematological malignancies.
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"Omacetaxine is a drug that has worked in CML in the past and we now find it to produce responses among CML patients who have the T315I mutation, a group that currently has no other pharmaceutical options," said principal investigator Jorge Cortes, M.D., professor in M.
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Omacetaxine launches different attack on CML that is impervious to other therapies
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Omacetaxine has a novel mechanism of action, and induces apoptosis by inhibition of protein synthesis, particularly Mcl-1.
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Omacetaxine mepesuccinate is a first-in-class cetaxine with demonstrated clinical activity as a single agent in a range of hematological malignancies.
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This phase 2 trial was designed to study the "Combination of Omacetaxine and Imatinib in the Treatment of Patients with CML in Advanced Stages or After Failure to Imatinib".
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"Omacetaxine is the first drug to show consistent activity in patients with chronic myeloid leukemia who are affected with the T315I mutation," said lead author Jorge Cortes, MD,
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Omacetaxine is an injectable drug that had been tested against leukemia in past decades but was shelved when imatinib came along.
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