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To test the roles of other oncogenes and environmental stimuli, Leder created a second OncoMouse, in which two activated proto-oncogenes, ras and myc, were engineered into the chromosome and expressed in breast cells.
In 1988, he successfully applied for a patent on the OncoMouse, making it the first animal patented in history.
Colloquially, Leder called his mouse the OncoMouse.
OncoMouse (cancer mouse) for research, through genetic redesign. restriction endonucleases, which are able to cut DNA at specific sites.
Scurrying about in its cage in the vivarium atop Harvard Medical School, Philip Leder’s OncoMouse bore large implications on small haunches.