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  • To test the roles of other oncogenes and environmental stimuli, Leder created a second OncoMouse, in which two activated proto-oncogenes, ras and myc, were engineered into the chromosome and expressed in breast cells.

    The Emperor of All Maladies

  • In 1988, he successfully applied for a patent on the OncoMouse, making it the first animal patented in history.

    The Emperor of All Maladies

  • Colloquially, Leder called his mouse the OncoMouse.

    The Emperor of All Maladies

  • OncoMouse (cancer mouse) for research, through genetic redesign. restriction endonucleases, which are able to cut DNA at specific sites.

    Citizendium, the Citizens' Compendium - Recent changes [en]

  • Scurrying about in its cage in the vivarium atop Harvard Medical School, Philip Leder’s OncoMouse bore large implications on small haunches.

    The Emperor of All Maladies


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