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Examples
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The genetic test is called Oncotype DX, developed by Genomic Health Inc. of Redwood City, Calif.
Mixed News on Breast Cancer Ron Winslow 2011
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The test, to be called the Oncotype DX colon-cancer test, is being developed by Genomic Health Inc., a Redwood City, Calif., company that sponsored the study and which plans to start selling the test early next year.
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Today many of the newer targeted cancer drugs—Avastin, Tarceva, Erbitux—are administered after genetic testing, while other FDA-approved diagnostic tests, such as Oncotype Dx, look at the expression of a few dozen genes to instruct whether breast cancer patients will benefit from tamoxifen.
The $1,000 Genome Kevin Davies 2010
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There's the Oncotype DX test which sorts out about different genes.
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When results were negative with IHC and FISH, they were also generally negative with Oncotype.
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Genomic's Oncotype employs reverse transcription polymerase chain reaction RT-PCR to check for HER2.
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Oncotype has been shown to be reliable in identifying estrogen receptor-positive and progesterone-positive tumors, she added.
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The discordances between tests are "not uncommon" and because of those discrepancies the company began including RT-PCR measurement of HER2 in Oncotype "with the goal of providing added clarity in cases where HER2 results by IHC and FISH are uncertain or conflicting," according to the statement.
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But all 23 equivocal results as reported by IHC and FISH came out negative with Oncotype, the investigators found.
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"None of us would request Oncotype for the sole purpose of getting HER2," she said.
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