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Examples
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Picoplatin is a cytotoxic platinum compound which causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription.
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Picoplatin has demonstrated anti-tumor activity in a variety of solid tumors.
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Picoplatin is intended to treat cancers as effectively as oxaliplatin but with less nerve damage.
Gaea Times (by Simple Thoughts) Breaking News and incisive views 24/7 2010
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The company has been hoping to show that Picoplatin is as effective as a regimen as the current standard of care while causing less nerve damage.
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They have said that nerve damage for patients who took Picoplatin occurred later in treatment and was less frequent and severe.
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Picoplatin was rationally designed to overcome a variety of platinum resistant mechanisms and as such, we believe may have significant potential within solid tumor indications where platinum agent was previously utilized, as well as where platinum agents have not been previously approved, such as in the treatment of prostate cancer.
Poniard Pharmaceuticals CEO Discusses Q3 2010 Results - Earnings Call Transcript -- Seeking Alpha 2010
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Picoplatin has demonstrated anti-tumor activity in a variety of solid tumors.
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Picoplatin is a new and differentiated platinum-based chemotherapeutic agent that is in clinical development for multiple cancer indications, treatment combinations and by two routes of administration.
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Picoplatin has been administrative to over 1100 patients to date and a growing body of positive clinical evidence demonstrates that this important drug candidate may have a significant and clinically meaningful therapeutic impact on multiple tumor types.
Poniard Pharmaceuticals CEO Discusses Q3 2010 Results - Earnings Call Transcript -- Seeking Alpha 2010
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In mid-November, Poniard told investors that Picoplatin did not significantly improve survival for lung cancer patients in a late-stage trial.
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