SSc

Authors write that although this trend had to do with improved detection and medical record techniques, higher incidence rates in women suggest that there “may have been a true increase in the incidence of SSc.”

The Autoimmune Epidemic Donna Jackson Nakazawa 2008

Authors write that although this trend had to do with improved detection and medical record techniques, higher incidence rates in women suggest that there “may have been a true increase in the incidence of SSc.”

The Autoimmune Epidemic Donna Jackson Nakazawa 2008

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death.

Naturejobs - All Jobs Timothy R D J Radstake 2010

Analysis of 279,621 autosomal SNPs followed by replication testing in an independent case-control set of European ancestry (2,753 individuals with SSc (cases) and 4,569 controls) identified a new susceptibility locus for systemic sclerosis at

Naturejobs - All Jobs Timothy R D J Radstake 2010

European ancestry including a total of 2,296 individuals with SSc and 5,171 controls.

Naturejobs - All Jobs Timothy R D J Radstake 2010

Furthermore, the serum from SSc and SLE patients cannot stimulate TLR4 expressing CHO cells to up-regulate CD25, which suggests that

PLoS ONE Alerts: New Articles Gang Wu et al. 2010

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death.

Naturejobs - All Jobs Timothy R D J Radstake 2010

To identify new SSc susceptibility loci, we conducted the first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls.

Naturejobs - All Jobs Timothy R D J Radstake 2010

Figure 1: Manhattan plot of the GWAS of the discovery cohort comprising 2,346 SSc cases and

Naturejobs - All Jobs Timothy R D J Radstake 2010

In contrast, the expression of TLR4 in systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) is lower than it is in RA.

PLoS ONE Alerts: New Articles Gang Wu et al. 2010