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Examples
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Subtype relationships that are used to dispatch GFs should be doable with plain predicates - pair? my-record-type? etc.
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Subtype relationships that are used to dispatch GFs should be doable with plain predicates - pair? my-record-type? etc.
Snell-Pym » Insomnia 2008
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I found the AA sequence of NL4-3 lab standard Subtype B and several recently entered SIV cpz sequences at the Los Alamos National Laboratory HIV Sequence Database4 – I got the same numbers.
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Two relatively well characterized subtypes are Subtype B and C.
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Group M is the one making a mess of the world right now, and is further divided into Subtype A, B, C, etc, and circulating recombinant forms of the subtypes Subtype AG, for instance.
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It turns out that one of the biochemical differences is that Subtype B Vps have a Golgi retention signal in the second alpha-helix of the cytoplasmic domain.13 This means that Subtypes B Vpu prefers if you will excuse me personifying a virus to be in the Golgi, helping degrade CD4, while Subtype C Vpu prefers to be in the plasma membrane, assisting with the release of new viruses.
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For instance, Subtype C Vpus are characteristically longer than the others, have key phosphorylation sites shifted, have an extra CKII site, and its tertiary structure is totally different Subtype B Vpus have an Mr of 43,000 in an SDS-PAGE gel, while Subtype C is 34,000.
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Subtype C HIV can be defined by its Vpu, as it is so different from the other subtypes.12
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Subtype-A is the second most common cause of infection (27%), followed by subtype-B strains (12. 3%).
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The programme is continuing to develop Subtype C vaccines and is at an advanced stage of laboratory testing of some of candidate vaccines.
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