from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A lymphocyte, from the thymus, that can recognise specific antigens and can activate or deactivate other immune cells.
from the GNU version of the Collaborative International Dictionary of English
- A type of white blood cell that circulates in the blood and lymph, and provides cell-mediated immunity for the organism, protecting against infecting cells or the body's own malignant cells; also called T lymphocyte. There are several types of T cells. They develop, as do B cells, from progenitor cells in the bone marrow, but are distinguished from B-cells (B-lymphocytes) by their site of differentiation; T-cells mature in the thymus and B-cells in the bone marrow (in birds in the Bursa of Fabricius). They also have different antigen receptors from those of B-cells. T-cells differentiate into cells that can directly kill infecting cells (cell-mediated immunity, cytotoxity) or activate other cells of the immune system (helper T cells), whereas B-cells differentiate on activation into antibody-secreting plasma cells. Helper T cells interact with B-cells by secreting lymphokines that stimulate the B cell which have detected a foreign antigen to enter the cell cycle and develop, by repeated mitosis, into a clone of cells with identical receptors, and then to secrete antibodies to that specific antigen.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
Sorry, no etymologies found.
Exposure to a metabolite of the environmental toxicant trichloroethylene attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding.
Lead enhances CD4+ T cell proliferation indirectly by targeting antigen presenting cells and modulating antigen-specific interactions.
Once a T cell’s antigen receptor finds an antigen has entered the body that it recognizes as foreign, the T cell forms what is known as an immunological synapse—think of it as a telephone call from the T cell to the dendritic cell—querying dendritic cells for additional information about the antigen and its source in the body.
Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity.
Trichloroethylene accelerates an autoimmune response in association with Th1 T cell activation in MRL+/+ mice.
Environmental contaminant trichloroethylene promotes autoimmune disease and inhibits T cell apoptosis in MRL+/+ mice.
CD4+ T cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice.
T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease.
Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation, J Pharmacol Exp Ther 2000 Sep; 2943:1146–53.
Cutting edge: Cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease.