T-antigen

The vector backbone also contains a simian virus 40 (SV40) replication origin, which is active in mammalian cells that express the SV40 T-antigen.

Archive 2005-10-01 2005

Although the expression of the T-antigen in beta-cells leads to a dramatic increase in beta-cell proliferation in adult mice, we found that beta-cell masses at embryonic day 16.5 were not significantly different either between wild-type mice with or without βTag expression as well as their PKO-βTag littermates (not shown).

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

The SV40 Large T-antigen (Tag) was genetically introduced into the insulin secreting beta-cells of

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

The SV40 Large T-antigen (Tag) was genetically introduced into the insulin secreting beta-cells of

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

Beta-cell proliferation is impaired in Perk-deficient, T-antigen transformed islets.

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

Although the T-antigen induction of beta-cell proliferation in

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

Recently, a Simian Virus-40 T-antigen (SV-40 Tag) targeted probasin promoter rat model was developed.

BioMed Central - Latest articles 2009

T-antigen induced beta-cell proliferation eventually leads to the formation of insulinomas

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

Perk-deficient mice was largely impaired, beta-cell mass was increased sufficiently by T-antigen induction to rescue the hypoinsulinemia and diabetes in these mice.

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009

Although T-antigen expression was able to induce beta-cell proliferation and reverse diabetes in the Beta-cell hyperplasia caused by T-antigen transformation reverses diabetes in Serum glucose levels (mg/dl) in wildtype (WT, closed squares and solid line), wildtype-βTag (WT-βTag, open squares and dashed line),

PLoS ONE Alerts: New Articles Sounak Gupta et al. 2009