Tolerability

Parallel-group, chronic Stable disease state Unethical to use active comparator treatment or placebo Crossover with washout Stable disease state Untreated washout not ethical Ethical to use placebo after active Sequential Rare disease Complicated tolerability pro fi le Homogeneous disease state Many concomitant disease factors Urgent need to save life 'N of 1' Stable disease state Few or no feasible alternative therapies 'Large simple' Very common disease Tolerability issues not closely related Easily measured end-points to ef fi cacy variable Well-understood drug Open label Tolerability issues only Spontaneous adverse event frequency high Within-patient Stable disease state Drug tolerance dose ranging Intolerable high initial dose Combination therapy A priori reason to expect favorable Unethical to use single therapy drug interaction

Recently Uploaded Slideshows martins0105 2009

The researchers analysed data from a nonrandomized Second-Generation Antipsychotic Treatment Indications, Effectiveness and Tolerability in Youth (SATIETY) cohort study, conducted between December 2001 and September 2007.

Dr. Sharma’s Obesity Notes » Blog Archive » Antipsychotic Medications and Weight Gain in Children and Adolescents 2009

Tolerability of a three-dose schedule of an investigational, multicomponent, meningococcal serogroup B vaccine and routine infant vaccines in a lot consistency trial.

Reuters: Press Release 2012

Completed dosing of the first cohort in the dose escalating phase of our START-FAP Safety and Tolerability of An RNAi Therapeutic in Familial Adenomatous Polyposis Phase 1b/2a clinical trial with CEQ508.

unknown title 2011

Main Outcome Measure (s) Tolerability to the procedure was evaluated by means of an 11-point (0 to 10) numeric rating scale of the pain experienced.

WN.com - Articles related to Crack and cocaine use a significant HIV risk factor for teens 2010

Main Outcome Measure (s) Tolerability to the procedure was evaluated by means of an 11-point (0 to 10) numeric rating scale of the pain experienced.

WN.com - Articles related to Crack and cocaine use a significant HIV risk factor for teens 2010

Main Outcome Measure (s) Tolerability to the procedure was evaluated by means of an 11-point (0 to 10) numeric rating scale of the pain experienced.

WN.com - Articles related to Crack and cocaine use a significant HIV risk factor for teens 2010

Tolerability of the drug is 'moderate', the FDA staff said, adding, 'it is not clear if labelling alone will be sufficient to alert women to the numerous drug interactions that exist with flibanserin'.

IOL: News 2010

Main Outcome Measure (s) Tolerability to the procedure was evaluated by means of an 11-point (0 to 10) numeric rating scale of the pain experienced.

WN.com - Articles related to Crack and cocaine use a significant HIV risk factor for teens 2010

Safety, Tolerability and preliminary activity of GS-9450, a selective caspase inhibitor, in patients with non-alcoholic steatohepatitis (NASH).

PhysOrg.com - latest science and technology news stories 2010