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Examples
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In healthy individuals, some intestinal T cells (known as Tregs) play a regulatory role, recognizing commensals and keeping the immune system from attacking them.
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The results showed that patients with high levels of an immune cell type called T-regulatory cells, or "Tregs" together with low levels of another type of immune cell, called Natural Killer cells, had risk more than five times higher.
Medindia Health News 2010
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We found that CD4+ T cells expressing both FoxP3 and Bcl-xL were able to differentiate into functional Tregs, which have a long-term survival advantage over cells transduced with FoxP3 alone.
BioMed Central - Latest articles Rizwanul Haque 2010
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In this study, we generated therapeutically active Tregs with an increased lifespan and hence greater therapeutic potential.
BioMed Central - Latest articles Rizwanul Haque 2010
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In an in vivo murine model, adoptive transfer of Tregs expressing both FoxP3 and Bcl-xL demonstrated more effective suppression of RA than CD4+ T cells expressing FoxP3 alone.
BioMed Central - Latest articles Rizwanul Haque 2010
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Our results provide a novel approach for generating highly reactive Tregs for augmenting cellular immunotherapy for autoimmune disease.
BioMed Central - Latest articles Rizwanul Haque 2010
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In addition, by using in vitro functional analyses and adoptive immunotherapy in a murine model of RA, we demonstrated that these Tregs were highly reactive.
BioMed Central - Latest articles Rizwanul Haque 2010
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Forkhead box p3 (FoxP3) - expressing regulatory T cells (Tregs) have been clearly implicated in the control of autoimmune disease in murine models.
BioMed Central - Latest articles Rizwanul Haque 2010
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We used retrovirus-mediated transduction to introduce FoxP3 or FoxP3 with anti-apoptotic Bcl-2 family molecule Bcl-xL linked by a 2A picornavirus self-cleaving peptide into CD4+ T cells to generate Tregs.
BioMed Central - Latest articles Rizwanul Haque 2010
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FoxP3 and Bcl-xL can cooperatively promote the differentiation and persistence of Tregs, with the capacity to prevent arthritis.
BioMed Central - Latest articles Rizwanul Haque 2010
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