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Examples
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At least in some cases, histone deacetylase inhibitors such as Trichostatin A is also required with de-methylating agents in order to restore gene expression in an otherwise densely methylated gene locus
PLoS ONE Alerts: New Articles Mehregan Movassagh et al. 2010
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A HDAC inhibitor Trichostatin A (TSA) induced apoptosis in the presence of survival-prolonging cytokines interleukin-5 and granulocyte-macrophage colony stimulating factor (GM-CSF) in eosinophils and neutrophils.
BioMed Central - Latest articles Hannu Kankaanranta 2010
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Combination of histone deacetylase inhibitor Trichostatin A (TSA) and 5-aza-dc significant decrease in nuclear expression of Di-methyl histone H3-Lys27 and slight increase in acetyl histone H3-Lys9 in MCF-7 cells.
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Newcastle showed that the drug, Trichostatin A, increased the levels of a protein subunit of PKA and also inhibited smooth muscle contractions in these tissues.
PhysOrg.com - latest science and technology news stories 2009
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The results showing that Trichostatin A can inhibit contractions in the uterus means it could have a role in preventing premature birth.
PhysOrg.com - latest science and technology news stories 2009
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E, Effect of Trichostatin A on Teashirt3-mediated inhibition of transactivation.
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For studies with the HDAC inhibitor Trichostatin A, 6 hours after transfection, 1mM Trichostatin A
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"The discovery that Trichostatin A can inhibit contractions means that this drug could potentially be used to prevent premature labour, however further laboratory studies are needed to assess the effectiveness of this and similar anti-cancer agents," the researchers said.
IrishHealth.com 2009
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Burnett BG, Taye AA, Gabanella F, Knight MA, et al. (2007) Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy.
PLoS ONE Alerts: New Articles Debra A. O'Leary et al. 2009
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Dr Magdalena Karolczak-Bayatti, Research Fellow, Newcastle University commented: "More laboratory research should help us to determine exactly how Trichostatin A regulates PKA levels and affects uterine muscle contraction."
PhysOrg.com - latest science and technology news stories 2009
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