from The Century Dictionary.
- noun In pathology, atrophy of the stratum spinosum (prickle-cells) of the epidermis.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine The loss of
intercellularconnections, resulting in loss of cohesionbetween keratinocytes, seen in diseasessuch as pemphigus vulgaris.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a breakdown of a cell layer in the epidermis (as in pemphigus)
from Wiktionary, Creative Commons Attribution/Share-Alike License
The skin showed hyperplasia and acantholysis in the mid - and lower epidermal layers, whereas the heart showed extensive fibrosis and fibrofatty replacement in both ventricles.
Activation of keratinocyte intracellular signaling pathways is emerging as an important component of pemphigus IgG-mediated acantholysis.
Furthermore, these observations suggest that the earlier peak of p38MAPK activation is part of the mechanism leading to acantholysis, whereas the later peak of p38MAPK and apoptosis may not be essential for acantholysis.