Definitions

from The Century Dictionary.

  • noun In pathology, atrophy of the stratum spinosum (prickle-cells) of the epidermis.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun medicine The loss of intercellular connections, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun a breakdown of a cell layer in the epidermis (as in pemphigus)

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

acanth (“spine”) +‎ -lysis (“destruction”)

Examples

  • The skin showed hyperplasia and acantholysis in the mid - and lower epidermal layers, whereas the heart showed extensive fibrosis and fibrofatty replacement in both ventricles.

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  • Activation of keratinocyte intracellular signaling pathways is emerging as an important component of pemphigus IgG-mediated acantholysis.

    Journal of Biological Chemistry current issue

  • Furthermore, these observations suggest that the earlier peak of p38MAPK activation is part of the mechanism leading to acantholysis, whereas the later peak of p38MAPK and apoptosis may not be essential for acantholysis.

    Journal of Biological Chemistry current issue

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