Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry The N-
acetyl derivative ofserotonin ; it is an intermediate in the biosynthesis ofmelatonin fromserotonin
Etymologies
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Examples
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N-acetylserotonin could stimulate TrkB even when BDNF was not present, both in cell culture dishes and in mice, Ye and his colleagues found.
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Melatonin's immediate precursor, N-acetylserotonin, was not previously thought to have effects separate from those of melatonin or serotonin.
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Ye's laboratory is now investigating the mechanism by which N-acetylserotonin activates TrkB.
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One of the most common strains of laboratory mice (C57Bl6) is deficient in making N-acetylserotonin and melatonin and develops retinal degeneration.
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"We were surprised to find that N-acetylserotonin, but not serotonin or melatonin, can activate TrkB."
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The authors observed that in the retinas of mice that produce adequate melatonin, TrkB is turned on at night, a pattern that matches the appearance of N-acetylserotonin.
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He says that N-acetylserotonin has a short lifetime in the body but similar compounds that are more stable may be useful in treating neurological diseases.
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Now an Emory team has shown that N-acetylserotonin can stimulate the same circuits in the brain activated by the growth factor BDNF (brain-derived neurotrophic factor).
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The discovery has implications for the study of how some antidepressants function and may also explain previous observations that N-acetylserotonin has antidepressant activity in animal models of depression.
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