Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry The N-
acetyl derivative ofserotonin ; it is an intermediate in the biosynthesis ofmelatonin fromserotonin
Etymologies
Sorry, no etymologies found.
Support

Help support Wordnik (and make this page ad-free) by adopting the word acetylserotonin.
Examples
-
N-acetylserotonin could stimulate TrkB even when BDNF was not present, both in cell culture dishes and in mice, Ye and his colleagues found.
-
Melatonin's immediate precursor, N-acetylserotonin, was not previously thought to have effects separate from those of melatonin or serotonin.
-
Ye's laboratory is now investigating the mechanism by which N-acetylserotonin activates TrkB.
-
One of the most common strains of laboratory mice (C57Bl6) is deficient in making N-acetylserotonin and melatonin and develops retinal degeneration.
-
"We were surprised to find that N-acetylserotonin, but not serotonin or melatonin, can activate TrkB."
-
The authors observed that in the retinas of mice that produce adequate melatonin, TrkB is turned on at night, a pattern that matches the appearance of N-acetylserotonin.
-
He says that N-acetylserotonin has a short lifetime in the body but similar compounds that are more stable may be useful in treating neurological diseases.
-
Now an Emory team has shown that N-acetylserotonin can stimulate the same circuits in the brain activated by the growth factor BDNF (brain-derived neurotrophic factor).
-
The discovery has implications for the study of how some antidepressants function and may also explain previous observations that N-acetylserotonin has antidepressant activity in animal models of depression.
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.