from The Century Dictionary.
- noun A salt formed by the union of aconitic acid with a base.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry Any
saltor esterof aconitic acid.
from Wiktionary, Creative Commons Attribution/Share-Alike License
"Dark chocolate reduced the urinary excretion of the stress hormone cortisol and catecholamines and partially normalized stress-related differences in energy metabolism (glycine, citrate, trans-aconitate, proline, β-alanine) and gut microbial activities (hippurate and p-cresol sulfate)."
The bound cis-aconitate intermediate must flip over, probably around a CH2COO - pivoting on the ferrous iron of the active site so that the enzyme bound proton can approach from the opposite faces of the intermediate in generating either of the products45.
Aconitate isomerase catalyzes the interconversion of cis - and trans-aconitate by a 1, 3 allylic rearrangement that uses the (pro-S) hydrogens of the two substrates.
The interconversion of citrate and isocitrate by aconitate hydratase was shown to occur with complete retention of the proton transferred between C2and C3 but with no retention of the OH - between C3 and C2.
This did not seem such a formidable task, although it was not until 1963 that Kenneth Hanson and I solved the historically important problem of the prochirality of citric acid7, which was necessary for me to gain a proper perspective on the aconitate hydratase reaction.
These include subunits of pyruvate synthase, aconitate hydratase, and succinyl-CoA synthetase.
Some mRNAs showed changes within 30 min of cis-aconitate addition, whereas others responded