from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of various red, often toxic, polypeptide antibiotics obtained from soil bacteria.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a class of toxic polypeptide antibiotics found in soil bacteria of genus Streptomyces.
from the GNU version of the Collaborative International Dictionary of English
- n. any of various red antibiotics isolated from soil bacteria with a three-ring heterocyclic nucleus with an attached peptide chain.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. any of various red antibiotics isolated from soil bacteria
Sorry, no etymologies found.
An enormous molecule shaped like an ancient Greek statue, with a small, headless torso and two extended wings, actinomycin D was later found to work by binding and damaging DNA.
Others, such as nitrogen mustard or actinomycin D, came from serendipitous sources, such as mustard gas or soil bacteria, found accidentally to kill cancer cells.
In the summer of 1954, Farber persuaded Waksman to send him a number of antibiotics, including actinomycin D, to repurpose them as antitumor agents by testing the drugs on a series of mouse tumors.
Farber found that actinomycin D, administered intravenously, potently inhibited the growth of these lung metastases, often producing remissions that lasted months.
Within months, the team had confirmed that X-rays and actinomycin D were remarkably synergistic, each multiplying the toxic effect of the other.
He has isolated, together with his students and associates, a number of new antibiotics, including actinomycin (1940), clavacin, streptothricin (1942), streptomycin (1943), grisein
Cells were harvested at the indicated time points (hours after addition of actinomycin or vehicle or transfection with agRNA).
After 2 d, actinomycin D (act D, 1 μg ml − 1) or vehicle was added to the medium.
(Pol I) are polyadenylated and accumulate markedly after treatment with low concentrations of actinomycin D (ActD), which blocks the synthesis of full-length rRNA.
Overexpression of L11 or actinomycin D-induced ribosomal stress increases this L11-MDM2 interaction and subsequent p53 stabilization