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- verb Third-person singular simple present indicative form of
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(A) ERAT acylates GAM-proghrelin, but not His-tagged proghrelin, nor other precursors.
While we have used a modified proghrelin as a substrate, as described below, this HEL enzyme is enzymatically distinct from the modifying enzyme ghrelin O-acyl transferase (GOAT) , , and most likely physiologically acylates proteins other than proghrelin.
ERAT acylates GAM-proghrelin, requires certain amino acids at the N-terminus of the acylated protein, and is specific for Ser5.