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- noun biochemistry The
amine(4-aminobutyl)guanidine which is a decarboxylationproduct of arginineand an intermediatein polyamine biosynthesis
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D. Dakin he investigated arginase, the ferment which hydrolyses arginine into urea and ornithine, and later he discovered agmatine in herring roe and devised a method for preparing it.
(NO synthase can be used to gain insight into the biological role of endogenous agmatine )  6 Stability pH-Stability 7.4
The cell adhesion on the agmatine containing substrates was comparable to that on plastic substrates and significantly enhanced with respect to the non-functionalized controls.
Aim of this work is the development and testing of novel amphoteric nanosized poly (amidoamine) hydrogel film incorporating 4-aminobutylguanidine (agmatine) moieties to create RGD-mimicking repeating units for promoting cell adhesion.
A systematic comparative study of the response of an epithelial cell line was performed on hydrogels with agmatine and on non-functionalized amphoteric poly (amidoamine) hydrogels and tissue culture plastic substrates.
In particular the incorporation of agmatine warrants good potential in the field of cell culturing and the development of supported functionalized hydrogels on cover glass are very promising substrates for applications in cell screening devices.
< 1, 3, 4, 7 > (complete inhibition ; very slightly, only l-isomer and in presence of tetrahydrobiopterin and NADPH ; only l-isomer, inhibits NO and citrulline production from l-arginine as well as superoxide formation in absence of tetrahydropterin ) [29, 38, 41, 42, 51] agmatine