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The fringes are not supported internally by muscles or skeletal structures, and they scale allometrically with the size of the lizard (Russell et al. 2001).
This compares well with the known oral bioavailability of this compound in This allometric relationship between body surface rats and dogs (83 and 72%, respectively). area and species body weight then allows for a simple conversion of drug doses across species (Figure 8.3), and allometrically equivalent doses of drugs (mg kgÀ1) can be calculated for any 8.2 Prediction from animals species (Table 8.4).
The predicted in vivo renal how important this was for the systemic clearance Cl for rat (estimated by multiplying the predicted of compound X in dog. hepatic Cl by 9) may be scaled allometrically to This is an example of how in vitro studies can be obtain a prediction for the human in vivo renal combined with in vivo preclinical data, leading to clearance.
Predicted total Cl was obtained by adding in renal Cl estimates which were, in turn, scaled allometrically (Y ¼ aW 0: 75). and/or microsomal protein binding).