Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adverb In an
allosteric manner - adverb With regard to
allostery
Etymologies
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Examples
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S, Song X, Reichart D, Du K, et al. (2008) Induced ncRNAs allosterically modify
PLoS Biology: New Articles Francesca De Santa et al. 2010
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Company has a broad intellectual property portfolio and deep pipeline of preclinical drug candidates that allosterically modulate SHIP1.
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Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to the viral RT and allosterically hinder DNA polymerization by impairing the mobility of particular RT domains
PLoS ONE Alerts: New Articles Hendrik Weisser et al. 2010
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Ampakines bind allosterically to the protein on brain cells called the AMPA receptor, which mediates rapid synaptic transmission.
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With the novel assumptions that tubulins can laterally interact in two different forms, and allosterically affect neighboring lateral interactions, we can explain existing experimental observations.
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We model the affect of PKA on PLC to be allosterically regulated and to have two conformational states, one whose activity is strongly enhanced by calcium and one whose activity is only weakly enhanced.
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How can an activator and an inhibitor have different effects on an allosterically regulated enzyme?
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However, it is worth noting that many members of the ALDH family are allosterically regulated (see for example
PLoS ONE Alerts: New Articles Christopher G. Langendorf et al. 2010
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