Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.
Etymologies
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Examples
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One of the hallmark signs of this debilitating disease is an aggregation of the protein alpha-synuclein which is found not only in the mid-brain but also in the brain stem and the olfactory bulb.
unknown title 2011
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"The potential ability of the potent antioxidant Ergo-D2TM to target and control alpha-synuclein is most exciting," stated Dr. Jack Rogers.
unknown title 2011
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It identified unusual forms of alpha-synuclein, a major component of Lewy bodies, which is a signature characteristic in the brain tissue of
Xoma and Elan: A Tale of Two Mismanaged Biotech Companies, Part 2 - Seeking Alpha 2011
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D to measure in vivo the efficacy of Ergo-D2TM in repressing alpha-synuclein translation and promoting the survival and viability of dopaminergic neurons using the transgenic mouse model for PD.
unknown title 2011
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Wypych J, Steavenson S, Louis JC, Citron M, et al. (1999) alpha-synuclein fibrillogenesis is nucleation-dependent.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, et al. (2006) Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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In transgenic mouse models of the Lewy body variant of Alzheimer's, Parkinson's-related alpha-synuclein proteins (green) and the beta-amyloid protein plaques (red) and tau protein tangles (blue) associated with Alzheimer's
WN.com - Articles related to Adult kids feel sting when mom picks favorites 2010
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Li HT, Lin DH, Luo XY, Zhang F, Ji LN, et al. (2005) Inhibition of alpha-synuclein fibrillization by dopamine analogs via reaction with the amino groups of alpha-synuclein.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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The new data show effective silencing of the alpha-synuclein gene with an RNAi therapeutic, in a pre-clinical trial, testing the technology on a group of non-human primates.
San Antonio Business News - Local San Antonio News | The San Antonio Business Journal 2010
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Tashiro M, Kojima M, Kihara H, Kasai K, Kamiyoshihara T, et al. (2008) Characterization of fibrillation process of alpha-synuclein at the initial stage.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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