Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun medicine A particular tissue plasminogen activator, used to dissolve blood clots

Etymologies

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Examples

  • In this study, the authors did a follow-up safety analysis from SITS-ISTR to assess the implementation of the longer time window after publication of the ECASS III and SITS-ISTR studies in September 2008, the effect on admission-to-treatment time, and to confirm or refute whether alteplase remains safe when given beyond 3 hours.

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  • Findings showed that the proportion of patients receiving alteplase treatment within 3-4. 5 hours in the last quarter of 2009 was three times higher than in the first quarter of 2008

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  • Philadelphia, USA, and Steven R Levine from State University of New York Health Science Center and School of Medicine, New York, USA, point out that despite the ample evidence of the efficacy and effectiveness of alteplase, neither the European Medicines Agency or the US Food and Drug Administration have approved alteplase for use in the extended time window.

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  • Previous research from ECASS III and SITS-ISTR has shown the benefit and safety of alteplase treatment in the 3-4. 5 hour window after stroke.

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  • Extension of the timeframe for alteplase treatment after acute stroke from 3 hours up to 4.5 hours is a safe option and has not resulted in delayed treatment of patients.

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  • Reperfusion of ischaemic brain IV alteplase (0·9 mg / kg, at most 90 mg),  With 10\% as a bolus followed by an Infusion Lasting 60 min: selected Patients within 3h of Onset of ischaemic Stroke Reduces the odds of death or Dependency at  Final follow-up by 44\% 110 people (50-170) from death or  Dependency for every 1000 treated

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  • The available agents today are tissue-type plasminogen activator or alteplase (tPA), reteplase, tenecteplase, urokinase, anisoylated purified streptokinase activator complex, and streptokinase.

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  • The mainstay of treatment in the last three to four years has been to dissolve the clot using a drug called tPA (alteplase).

    Health News from Medical News Today

  • Hacke W et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.

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  • Actilyse® (active ingredient: alteplase), is approved for use within 3 hours from the onset of ischaemic stroke.

    Health News from Medical News Today

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