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Examples
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Early Work • Discovered by Folkman in early 1970's • Link between vascular GF's and neovascularization associated with tumor growth • In 1983, Kumar et al. studied the presence of an "angiogenesis factor" in the human heart following MI • Mid-1980's: several polypeptide growth factors associated with angiogenesis identified and purified • As a result, animal and human studies could be expanded • Pre-clinical animal studies used an ameroid constrictor to gradually occlude one of the coronary arteries.
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