from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of chemical compounds that enhance attention span and alertness and facilitate learning and memory.


See AMPA. (Wiktionary)


  • The neurons in slice one have been treated with a type of drug known as an ampakine, while those in slice two have not.

    Brain chemistry: Good news and bad news

  • Ren J, Lorier AR, Funk GD, Greer JJ (2007) Whole-cell patch analyses of ampakine actions on respiratory medullaryneurons in perimatal medullary slice preparations.

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  • Kessler M (2007) Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior.

    PLoS ONE Alerts: New Articles

  • Kessler M, Rogers G, Lynch G (2000) Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466.

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  • Treatment with the ampakine did not produce overt side effects in the mice.

    Health News from Medical News Today

  • Prof. Lynch tested whether ampakine-mediated up-regulation of BDNF could restore the deficits in learning in a mouse model of Huntington's disease.

    Health News from Medical News Today

  • The researchers found that twice-daily injections of the ampakine normalized BDNF levels, and restored the molecular aspects underlying memory processes such as actin polymerization in dendritic spines, and a process called long-term potentiation, or LTP in eight-week-old mice.

    Health News from Medical News Today

  • Treating mice with the ampakine molecule CX929, a compound developed by Irvine-based Cortex Pharmaceuticals, produced dramatic improvements in the ability of test animals to create and store memories.

    Health News from Medical News Today

  • Several ampakine molecules are currently in human clinical trials.

    Health News from Medical News Today

  • Neurobiologists Gary Lynch, Danielle Simmons found that a mild ampakine treatment on mice produced dramatic amounts of the brain's own chemicals that create and store memories.



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