from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A starchlike substance.
- noun Medicine A hard waxy deposit consisting of protein and polysaccharides that results from the degeneration of tissue.
- adjective Starchlike.
from The Century Dictionary.
- Resembling amylum, or starch.
- noun In botany, a semi-gelatinous substance, analogous to starch, met with in some seeds, and becoming yellow in water after having been colored blue by iodine (Lindley); a member of the cellulose group of vegetable organic compounds, comprising cellulose, starch, gum, the sugars, etc.
- In pathology, noting a degenerative change characteristic of lardaceous disease (which see, under
- noun A precipitate obtained from a gelatinous solution of cotton which has been treated with concentrated sulphuric acid. Vegetable parchment is due to the partial transformation of the vegetable fibers into this substance.
- noun In pathology, same as
from the GNU version of the Collaborative International Dictionary of English.
- noun A non-nitrogenous starchy food; a starchlike substance.
- noun (Med.) The substance deposited in the organs in amyloid degeneration.
- adjective Resembling or containing amyl; starchlike.
- adjective (Med.) a diseased condition of various organs of the body, produced by the deposit of an albuminous substance, giving a blue color with iodine and sulphuric acid; -- called also
waxy degenerationor lardaceous degeneration.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A waxy compound of
proteinand polysaccharidesthat is found deposited in tissues in amyloidosis.
- noun Any of various
- adjective Containing or resembling
- adjective mycology Applied to a mushroom that turns blue-black upon application of Melzer's reagent.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a non-nitrogenous food substance consisting chiefly of starch; any substance resembling starch
- adjective resembling starch
- noun (pathology) a waxy translucent complex protein resembling starch that results from degeneration of tissue
from Wiktionary, Creative Commons Attribution/Share-Alike License
Scientists say a protein called beta amyloid is responsible for most of the damage to the brain and the symptoms of the disease.
Scientists have shown how the body's natural way of ridding the body of the toxic protein amyloid-beta is flawed in people with the disease.
No one knew where this pesky filament came from until 1987, when researchers discovered it was part of a larger molecule they dubbed the amyloid-precursor protein (APP).
But over the years, researchers say, what has become known as the amyloid hypothesis - the notion that overproduction or reduced clearance of amyloid beta is a cause of the disease and blocking amyloid beta could stop it - dominated their thinking.
"They work hand in hand, one after the other and act like scissors, cutting up this [APP] protein into smaller bits and smaller bits called amyloid peptide, which we think is the cause of Alzheimer's disease when it's abnormally accumulated in the brain," explained study senior author Philip C. Wong, a professor of pathology and of neuroscience at Johns Hopkins University School of Medicine in Baltimore.
Among the possible advances in early detection are chemical tracers, some of which tag clumps of a sticky substance in the brain called amyloid, and others that mark amyloid and a protein called tau—both thought to contribute to the disease.
The radioactive chemicals tag amyloid in the brain and light up during subsequent brain scans, allowing clinicians to see whether amyloid is present.
A large number of investigational therapies target a sticky substance called amyloid, which clumps in the brain of those with Alzheimer's and is thought to contribute to the disease, but so far no drug has consistently shown that targeting amyloid leads to improvements in cognitive symptoms.
The buildup of tangled proteins called amyloid plaques in brain tissue is a primary marker of Alzheimer's disease.
The exact causes of Alzheimer's are still unknown, but clumps of a sticky substance called amyloid and masses of tau protein in the brain are thought to be key factors in its development.