from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Reversion of cells to an immature or a less differentiated form, as occurs in most malignant tumors.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A reversion of differentiation in cells that is characteristic of malignancy in tumours
from the GNU version of the Collaborative International Dictionary of English
- n. loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor.
from The Century Dictionary and Cyclopedia
- n. In pathology, the sum of the morphological, structural, chemical, and other alterations which cells undergo when assuming the characteristics of malignancy.
- n. Same as anaplasis.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor
In MB, over-expression of c-MYC has been shown to cause anaplasia and correlate with unfavorable prognosis.