from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein that inhibits angiogenesis; it is used to inhibit the growth of new blood vessels in tumours


from The American Heritage® Dictionary of the English Language, 4th Edition

angio(genesis) + -stat + -in.


  • They are called angiostatin receptor blockers and they are given to heart failure patients, to blood pressure patients.

    CNN Transcript Jul 28, 2008

  • The angiostatin trials, taking place at Thomas Jefferson University Hospital in Philadelphia, are still getting underway.

    Folkman Looks Ahead

  • At least 20 drugs called angiogenesis inhibitors are now in clinical trials, including angiostatin and endostatin, the compounds isolated by Dr. Michael O'Reilly in Folkman's lab.

    Folkman Looks Ahead

  • AMOTL2 belongs to the angiomotin family which mediates inhibition of endothelial cell migration and tube formation by binding to angiostatin

    PLoS ONE Alerts: New Articles

  • The popularity of the idea waned in the early 2000s following disappointing results in clinical trials of two anti-angiogenic compounds, angiostatin and endostatin, that were discovered in Folkman's lab.

    Latest Articles

  • Some bio - therapeutic treatments include gene therapy, to replace or repair damaged genes or to boost the immune system; Angiogenesis inhibitors like angiostatin and endostatin, that cut off the blood supply to tumors, depriving them of the nourishment they need to grow; antisense therapy that blocks the formation of important proteins that keep cancer cells from growing and spreading; and monoclonal antibodies, biological smart bombs that target select portions of cancer cells, leaving healthy tissue alone.

    CNN Transcript - Special Event: Millennium 2000: Cancer - January 2, 2000


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