from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The form of apoptosis, or programmed cell death, that occurs when a cell becomes dislodged from its matrix


Pseudo-Greek coinage intended to have the sense "homelessness". Compare Ancient Greek ἄνοικος (anoikos, "homeless wanderer"). (Wiktionary)


  • Acquisition of resistance to "anoikis" facilitates the survival of cells under independent matrix-deficient conditions, such as cells in tumor progression and the production of suspension culture cells for biomedical engineering.

    BioMed Central - Latest articles

  • Moreover, the disruption of the interaction between epithelial cells and extracellular matrix ( 'anoikis') may play an important role in the onset of apoptosis in detached enterocytes

    PLoS ONE Alerts: New Articles

  • Apoptosis of detaching enterocytes after intestinal IR is potentially caused by loss of contact between the epithelial cells and extracellular matrix, and between neighbouring epithelial cells ( 'anoikis') [20], [31], [34].

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  • There's a Greek term we use, anoikis, that means homeless -- humans have evolved so that healthy cells would rather be dead than in the wrong home.

    Leading the Hunt For Cancer Genes

  • Detjen K, Welzel M, von MZ, Murphy D, et al. (2000) A novel function for the tumor suppressor p16 (INK4a): induction of anoikis via upregulation of the alpha (5) beta (1) fibronectin receptor.

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  • Welzel M, Daskalow K, Pfander D, Wiedenmann B, et al. (2008) Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin.

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  • Sood and his team first studied the effects of stress hormones on human ovarian cancer cell anoikis in culture.


  • Cells that detach from their environment undergo a form of programmed cell death called anoikis.


  • The stress hormone treatment activated a protein called FAK (focal adhesion kinase), which is known to protect cells from anoikis.


  • "But cancer cells have come up with way to bypass this effect-they avoid anoikis," Sood says.



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