anti-apoptotic love

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Examples

  • A paper published online on May 5 in the Journal of Medicinal Chemistry describes how BI-97C1, an optically pure derivative of a cottonseed extract called gossypol, inhibits all six anti-apoptotic Bcl -2 family proteins.

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  • As a result, any therapy designed to defeat these proteins, and thus enhance the cell death caused by most cancer treatments, must target the exact anti-apoptotic protein the cancer is expressing to be effective.

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  • In athymic nu/nu mouse model, we further demonstrated that MA significantly suppressed pancreatic tumor growth, induced tumor apoptosis, and inhibited NF-kappaB-regulated anti-apoptotic gene expression, such as Survivin and Bcl-xl.

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  • Medical Research Institute (Sanford-Burnham) has made two recent discoveries that may help curb these anti-apoptotic proteins and make current treatments more effective.

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  • "You need to inhibit all six of the anti-apoptotic proteins members of the Bcl-2 family to have a compound with therapeutic potential," says Dr. Pellecchia.

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  • In this context we also found that overexpression of the anti-apoptotic and pro-survival protein bcl-2, in human melanoma and breast carcinoma cells, under hypoxia, enhances HIF-1α protein expression and HIF-1 activity consequently leading to angiogenesis through vascular endothelial growth factor (VEGF)

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  • BCL2 is best known as a multifunctional anti-apoptotic protein.

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  • BCL2 is best known as a multifunctional anti-apoptotic protein.

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  • BCL2 is best known as a multifunctional anti-apoptotic protein.

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  • In a paper published online in the journal Cell Death and Disease on May 6, Maurizio Pellecchia, Ph. D., and colleagues outline how the six anti-apoptotic proteins in the Bcl-2 family are expressed differently in different cancers.

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