Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. That inhibits the activity of folic acid
  • n. Any drug that inhibits the activity of folic acid; a folate antagonist

Etymologies

Sorry, no etymologies found.

Examples

  • Some, such as aminopterin or methotrexate, were the products of inspired guesswork by scientists Farber had discovered aminopterin by guessing that an antifolate might block the growth of leukemia cells.

    The Emperor of All Maladies

  • On December 28, however, Farber received a new version of antifolate from Subbarao and Kiltie, aminopterin, a chemical with a small change from the structure of PAA.

    The Emperor of All Maladies

  • If folic acid accelerated the leukemia cells in children, what if he could cut off its supply with some other drug—an antifolate?

    The Emperor of All Maladies

  • MTX is much more (1000 times more) prone to bind dihydrofolate reductasethan folic acid, and thus is an effective antifolate (something that keeps folic acid from doing its job).

    Psoriasis Guru » Blog Archive » How Does Methotrexate Work?

  • In addition to Droxidopa, Chelsea is also developing a portfolio of metabolically inert oral antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity to treat a range of immunological disorders, including two clinical stage product candidates: CH-1504 and CH-4051.

  • Three of the mutants maintained activity but also displayed lower affinity for the drug molecule, a propargyl-linked antifolate inhibitor.

    PhysOrg.com - latest science and technology news stories

  • Its key compounds are an antifolate to treat rheumatoid arthritis and Droxidopa, which is used for the treatment of neurogenic orthostatic hypotension.

    Dallas Business News - Local Dallas News | Dallas Business Journal

  • Nduati E, Mberu EK, Hopkins Sibley C, Monks SA, et al. (2000) Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.

    PLoS ONE Alerts: New Articles

  • Methotrexate is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.

    PLoS ONE Alerts: New Articles

  • In addition to Northera, Chelsea is also developing a portfolio of metabolically inert oral antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity to treat a range of immunological disorders, including two clinical stage product candidates: CH-1504 and CH-4051.

    News

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.