Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • adj. Slang Restless or impatient; fidgety: The long wait made the children antsy.
  • adj. Slang Nervous; apprehensive: "Camps got shot up all the time, but if there wasn't a shoot-up, they'd get antsy” ( Harper's).

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. restless, apprehensive and fidgety

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • adj. nervous and unable to relax

Etymologies

Perhaps from the incessant motions of ants.
(American Heritage® Dictionary of the English Language, Fourth Edition)
From ants +‎ -y, as in ants in one's pants. The term antsy was first noted as a rural Southern USA figure of speech in the early 20th century. (Wiktionary)

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