Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
drug that acts as apartial agonist selective for thedopamine receptor D2.
Etymologies
Sorry, no etymologies found.
Support
Help support Wordnik (and make this page ad-free) by adopting the word aplindore.
Examples
-
This opens the possibility of dosing aplindore in RLS without prior titration.
-
-- (BUSINESS WIRE) -- Neurogen Corporation (Nasdaq: NRGN - News) today announced positive top-line results from two Phase 2 clinical trials in restless legs syndrome (RLS) and Parkinson's disease with the Company's dopamine partial agonist, aplindore.
-
In addition, aplindore was generally well tolerated and there were no withdrawals due to adverse events and no serious adverse events.
-
Patients titrated to higher aplindore doses (9 mg BID and 15 mg BID) over the same two-week period of time showed improvements that did not separate statistically from placebo.
-
In addition, aplindore was well tolerated with an incidence of adverse events similar to placebo in doses up to 0.2 mg.
-
These studies were the first in which aplindore has been evaluated in RLS and Parkinson's disease.
-
Patients titrated to higher aplindore doses (9 mg BID and 15 mg BID) over the same two-week period of time showed improvements that did not separate statistically from placebo.
-
Additionally, the study was designed to generate efficacy data with aplindore compared to placebo as measured by the mean change in the Unified Parkinson's Disease Rating Scale (UPDRS)
-
This finding suggests a possible decrease or plateauing of the observed effect in the upper dose range and that the future evaluation of aplindore should focus on the lower dose ranges.
-
Additionally, the study was designed to generate efficacy data with aplindore compared to placebo as measured by the mean change in the Unified Parkinson's Disease Rating Scale (UPDRS)
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.